Model-based strategy for cell culture seed train layout verified at lab scale
نویسندگان
چکیده
منابع مشابه
Model-based strategy for cell culture seed train layout verified at lab scale.
Cell culture seed trains-the generation of a sufficient viable cell number for the inoculation of the production scale bioreactor, starting from incubator scale-are time- and cost-intensive. Accordingly, a seed train offers potential for optimization regarding its layout and the corresponding proceedings. A tool has been developed to determine the optimal points in time for cell passaging from ...
متن کاملSeed train optimization for suspension cell culture
Introduction The purpose of a seed train is the generation of an adequate number of cells for the inoculation of a production bioreactor. This is timeand cost-intensive: From volumes used for cell thawing or cell line maintenance the cell number has to be increased. The cells are usually run through many cultivation systems which become larger with each passage (e.g. T-flasks, roller bottles or...
متن کاملModel-based design of the first steps of a seed train for cell culture processes
Concept Production of biopharmaceuticals for diagnostic and therapeutic applications with suspension cells in bioreactors requires a seed train up to production scale [1]. For the final process steps in pilot and production scale the scale-up steps are usually defined (e.g. a factor of 5 10). More difficult in this respect are the first steps, the transitions between T-flasks, spinner tubes, ro...
متن کاملA Mathematical Model for Integrating Cell Formation Problem with Machine Layout
This paper deals with the cellular manufacturing system (CMS) that is based on group technology concepts. CMS is defined as identifying the similar parts that are processed on the same machines and then grouping them as a cell. The most proposed models for solving CMS are focused on cell formation problem while machine layout is considered in few papers. This paper addresses a mathematical mo...
متن کاملA Shot at Dendritic Cell-Based Vaccine Strategy against HIV-1
Introduction: Despite considerable efforts to control AIDS pandemic, it is still one of the significant infectious concerns worldwide. The advance in medical research has led to the development of highly active antiretroviral therapy with a considerable effect to suppress the disease. However, an effective vaccine capable of eradication the HIV pandemic is not available yet. Failure to develop ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2015
ISSN: 1753-6561
DOI: 10.1186/1753-6561-9-s9-p44